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1996-03-04
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Document 0741
DOCN M9640741
TI Incidence proportion of and risk factors for AIDS patients diagnosed
with HIV dementia, central nervous system toxoplasmosis, and
cryptococcal meningitis.
DT 9604
AU Wang F; So Y; Vittinghoff E; Malani H; Reingold A; Lewis E; Giordano J;
Janssen R; School of Public Health, University of California/Berkeley,
USA.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):75-82.
Unique Identifier : AIDSLINE MED/96142204
AB We undertook this study to determine the incidence proportion of and
risk factors for AIDS patients diagnosed with human immunodeficiency
virus (HIV) dementia, central nervous system (CNS) toxoplasmosis, and
cryptococcal meningitis. A historical cohort of 487 consecutive
inpatients with AIDS treated by San Francisco General Hospital inpatient
and outpatient services entered the study. We abstracted all available
records for demographic information, diagnoses, and dates of death and
estimated the incidence proportion of AIDS patients diagnosed with major
CNS complications using the Kaplan-Meier method. We used the Cox
proportional hazards model to analyze the effect of demographic factors
on the hazard (risk per unit time) of diagnosis with these CNS
conditions. The estimated incidence proportion of patients diagnosed
with HIV dementia within 1 and 2 years of AIDS diagnosis increased from
0.10 to 0.18. Corresponding proportions were 0.10 and 0.19 for CNS
toxoplasmosis and 0.10 and 0.14 for cryptococcal meningitis. Only HIV
dementia was independently associated with increasing age at AIDS
diagnosis (relative hazard [RH] of 2.75 for ages 41-50 [95% confidence
interval, 1.08-6.98]; RH of 4.73 for ages > 50 [95% confidence interval,
1.41-15.87]) and with injection drug use (RH of 2.03; 95% confidence
interval, 1.19-3.47). HIV dementia, CNS toxoplasmosis, and cryptococcal
meningitis are about equally common complications in patients with AIDS,
but only HIV dementia is associated with increasing age at AIDS
diagnosis and injection drug use.
DE Adult Aged AIDS Dementia Complex/COMPLICATIONS/*EPIDEMIOLOGY
AIDS-Related Opportunistic Infections/COMPLICATIONS/*EPIDEMIOLOGY
Cohort Studies Female Human Incidence Male Meningitis,
Cryptococcal/COMPLICATIONS/*EPIDEMIOLOGY Middle Age Multivariate
Analysis Proportional Hazards Models Risk Factors San
Francisco/EPIDEMIOLOGY Support, Non-U.S. Gov't Toxoplasmosis,
Cerebral/COMPLICATIONS/*EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).